Zhenglong Gu Laboratory:Home

Gu Laboratory: home

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The lab started by investigating the evolution of aerobic fermentation in yeasts. The similarity between yeast evolution and metabolic changes cancers called our attention to mitochondrion, the metabolic, energetic and signaling hubs of eukaryotic cells. The mitochondrion is an essential organelle, as it functions as the "power plant" for the cell, producing most of a cell's energy in the form of ATP. Mitochondria are also the centers of signal transduction controlling many biological pathways. Due to the functional importance of mitochondria and high mutation rate in mtDNA, we use a combination of computational and experimental approaches to investigate the roles of mtDNA mutation in diseases. We are also interested in using mitochondria as a system to investigate how gene regulation evolves in nature.