Zhenglong Gu Laboratory: Publications

Selected Publications:

See the full list of publications and citations from Google Scholar: https://scholar.google.com/citations?user=4ghczSgAAAAJ&hl=en

Association of mitochondrial DNA variants with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) symptoms MR Hanson, Z Gu, A Keinan, K Ye, A Germain, P Billing-Ross Journal of Translational Medicine 14 (1), 342	2016
Genetic Evidence for Elevated Pathogenicity of Mitochondrial DNA Heteroplasmy in Autism Spectrum Disorder Y Wang, M Picard, Z Gu PLoS Genet 12 (10), e1006391	2016
Coordinated Evolution of Transcriptional and Post-Transcriptional Regulation for Mitochondrial Functions in Yeast Strains X Sun, Z Wang, X Guo, H Li, Z Gu PloS one 11 (4), e0153523	2016
RNA Sequencing: A Novel FADS2 Isoform Identified in Milk Fat Globule Suppresses FADS2 Mediated Delta 6-Desaturation of Omega-3 Fatty Acids KSD Kothapalli, HG Park, X Guo, X Sun, J Zou, SS Hyon, X Qin, ... The FASEB Journal 30 (1 Supplement), 684.12-684.12	2016
Positive selection on a regulatory insertion-deletion polymorphism in FADS2 influences apparent endogenous synthesis of arachidonic acid KSD Kothapalli, K Ye, MS Gadgil, SE Carlson, KO O’Brien, JY Zhang, ... Molecular biology and evolution, msw049	2016
Mitochondrial DNA variants correlate with symptoms in myalgic encephalomyelitis/chronic fatigue syndrome P Billing-Ross, A Germain, K Ye, A Keinan, Z Gu, MR Hanson Journal of translational medicine 14 (1), 19	2016
Very Short Mitochondrial DNA Fragments and Heteroplasmy in Human Plasma R Zhang, K Nakahira, X Guo, AMK Choi, Z Gu Scientific Reports 6	2016
MBE Advance Access published March 29, 2016 KSD Kothapalli, K Ye, MS Gadgil, SE Carlson, KO O’Brien, JY Zhang, ...	2016
A robust and efficient method for estimating enzyme complex abundance and metabolic flux from expression data BE Barker, N Sadagopan, Y Wang, K Smallbone, CR Myers, H Xi, ... Computational biology and chemistry 59, 98-112	2015
Natural selection on HFE in Asian populations contributes to enhanced non-heme iron absorption K Ye, C Cao, X Lin, KO O’Brien, Z Gu BMC genetics 16 (1), 61	2015
Evolution of gene regulation during transcription and translation Z Wang, X Sun, Y Zhao, X Guo, H Jiang, H Li, Z Gu Genome biology and evolution 7 (4), 1155-1167	2015
Diminishing returns in next-generation sequencing (NGS) transcriptome data R Lei, K Ye, Z Gu, X Sun Gene 557 (1), 82-87	2015
Dynamic Epistasis under Varying Environmental Perturbations B Barker, L Xu, Z Gu PloS one 10 (1), e0114911	2015
Coordinating expression of RNA binding proteins with their mRNA targets H Jiang, L Xu, Z Wang, J Keene, Z Gu Scientific reports 4, 7175	2014
Reply to Just et al.: Mitochondrial DNA heteroplasmy could be reliably detected with massively parallel sequencing technologies K Ye, J Lu, F Ma, A Keinan, Z Gu Proceedings of the National Academy of Sciences 111 (43), E4548-E4550	2014
Nutritional Genomics Z Gu, K Ye, PJ Stover Genomic Medicine: Principles and Practice, 180	2014
Extensive pathogenicity of mitochondrial heteroplasmy in healthy human individuals K Ye, J Lu, F Ma, A Keinan, Z Gu Proceedings of the National Academy of Sciences 111 (29), 10654-10659	2014
Genome structure and dynamics of the yeast pathogen Candida glabrata KM Ahmad, J Kokošar, X Guo, Z Gu, OP Ishchuk, J Piškur FEMS yeast research 14 (4), 529-535	2014
Alternative transcripts in the human milk fat globule proteinogenic RNA transcriptome with emphasis on desaturases (818.8) K Kothapalli, X Guo, X Sun, S Hyon, R Ran-Ressler, J Zou, Z Gu, ... The FASEB Journal 28 (1 Supplement), 818.8	2014
Computational approaches for understanding energy metabolism AA Shestov, B Barker, Z Gu, JW Locasale Wiley Interdisciplinary Reviews: Systems Biology and Medicine 5 (6), 733-750	2013
Human expression QTLs are enriched in signals of environmental adaptation K Ye, J Lu, SM Raj, Z Gu Genome biology and evolution 5 (9), 1689-1701	2013
High-resolution view of bacteriophage lambda gene expression by ribosome profiling X Liu, H Jiang, Z Gu, JW Roberts Proceedings of the National Academy of Sciences 110 (29), 11928-11933	2013
Rewiring of posttranscriptional RNA regulons: Puf4p in fungi as an example H Jiang, X Guo, L Xu, Z Gu Molecular biology and evolution 29 (9), 2169-2176	2012
Dynamic epistasis for different alleles of the same gene L Xu, B Barker, Z Gu Proceedings of the National Academy of Sciences 109 (26), 10420-10425	2012
A mutation in intracellular loop 4 affects the drug-efflux activity of the yeast multidrug resistance ABC transporter Pdr5p X Guo, J Li, T Wang, Z Liu, X Chen, Y Li, Z Gu, X Mao, W Guan, Y Li PloS one 7 (1), e29520	2012
Recent advances in understanding the role of nutrition in human genome evolution K Ye, Z Gu Advances in Nutrition: An International Review Journal 2 (6), 486-496	2011
A conserved structural determinant located at the interdomain region of mammalian inositol-requiring enzyme 1α Z Xue, Y He, K Ye, Z Gu, Y Mao, L Qi Journal of Biological Chemistry 286 (35), 30859-30866	2011
Predominant gain of promoter TATA box after gene duplication associated with stress responses Y Zou, W Huang, Z Gu, X Gu Molecular biology and evolution, msr116	2011
Genetic architecture of growth traits revealed by global epistatic interactions L Xu, H Jiang, H Chen, Z Gu Genome biology and evolution 3, 909-914	2011
Growth of novel epistatic interactions by gene duplication H Jiang, L Xu, Z Gu Genome Biology and Evolution 3, 295-301	2011
Detection of heterozygous mutations in the genome of mismatch repair defective diploid yeast using a Bayesian approach S Zanders, X Ma, A RoyChoudhury, RD Hernandez, A Demogines, ... Genetics 186 (2), 493	2010
The baker's yeast diploid genome is remarkably stable in vegetative growth and meiosis KT Nishant, W Wei, E Mancera, JL Argueso, A Schlattl, N Delhomme, ... PLoS Genet 6 (9), e1001109	2010
Tinkering evolution of post-transcriptional RNA regulons: puf3p in fungi as an example H Jiang, W Guan, Z Gu PLoS Genet 6 (7), e1001030	2010
Antagonistic changes in sensitivity to antifungal drugs by mutations of an important ABC transporter gene in a fungal pathogen W Guan, H Jiang, X Guo, E Mancera, L Xu, Y Li, L Steinmetz, Y Li, Z Gu PLoS One 5 (6), e11309	2010
Detecting positive selection in the budding yeast genome YD LI, H Liang, Z Gu, Z Lin, W Guan, L Zhou, YQ LI, WH LI Journal of evolutionary biology 22 (12), 2430-2437	2009
Origins of digestive RNases in leaf monkeys are an open question Z Su, L Xu, Z Gu, X Gu Molecular Phylogenetics and Evolution 53 (2), 610-611	2009
Yeasts as models in evolutionary biology Z Gu, S Oliver Genome Biology 10 (3), 304	2009
Evolution of RNases in leaf monkeys: being parallel gene duplications or parallel gene conversions is a problem of molecular phylogeny L Xu, Z Su, Z Gu, X Gu Mol Phylogenet Evol 50, 397-400	2009
Differential selection on gene translation efficiency between the filamentous fungus Ashbya gossypii and yeasts H Jiang, Y Zhang, J Sun, W Wang, Z Gu BMC evolutionary biology 8 (1), 343	2008
Regulation dynamics of WGD genes during yeast metabolic oscillation H Chen, L Xu, Z Gu Molecular biology and evolution 25 (12), 2513-2516	2008
Relaxation of yeast mitochondrial functions after whole-genome duplication H Jiang, W Guan, D Pinney, W Wang, Z Gu Genome research 18 (9), 1466-1471	2008
Genome sequencing and comparative analysis of Saccharomyces cerevisiae strain YJM789 W Wei, JH McCusker, RW Hyman, T Jones, Y Ning, Z Cao, Z Gu, D Bruno, ... Proceedings of the National Academy of Sciences 104 (31), 12825	2007
Rapid evolution in a pair of recent duplicate segments of rice H Jiang, D Liu, Z Gu, W Wang Journal of Experimental Zoology Part B: Molecular and Developmental ...	2007
Molecular mechanisms involved in robustness of yeast central metabolism against null mutations N Maltsev, EM Glass, G Ovchinnikova, Z Gu Journal of biochemistry 137 (2), 177	2005
Elevated evolutionary rates in the laboratory strain of Saccharomyces cerevisiae Z Gu, L David, D Petrov, T Jones, RW Davis, LM Steinmetz Proceedings of the National Academy of Sciences of the United States of ...	2005
Comparative methods for the analysis of gene-expression evolution: an example using yeast functional genomic data TH Oakley, Z Gu, E Abouheif, NH Patel, WH Li Molecular biology and evolution 22 (1), 40-50	2005
Higher gene duplicabilities for metabolic proteins than for nonmetabolic proteins in yeast and E. coli E Marland, A Prachumwat, N Maltsev, Z Gu, WH Li Journal of molecular evolution 59 (6), 806-814	2004
Duplicate genes increase gene expression diversity within and between species Z Gu, SA Rifkin, KP White, WH Li Nature genetics 36 (6), 577	2004
Different evolutionary patterns between young duplicate genes in the human genome P Zhang, Z Gu, WH Li Genome biology 4 (9), R56	2003
Rate of protein evolution versus fitness effect of gene deletion J Yang, Z Gu, WH Li Molecular biology and evolution 20 (5), 772-774	2003
Detection of gene duplications and block duplications in eukaryotic genomes WH Li, Z Gu, ARO Cavalcanti, A Nekrutenko Journal of Structural and Functional Genomics 3 (1), 27-34	2003
Role of duplicate genes in genetic robustness against null mutations Z Gu, LM Steinmetz, X Gu, C Scharfe, RW Davis, WH Li Nature 421 (6918), 63-66	2003
Patterns of gene duplication in Saccharomyces cerevisiae and Caenorhabditis elegans ARO Cavalcanti, R Ferreira, Z Gu, WH Li Journal of molecular evolution 56 (1), 28-37	2003
Rapid divergence in expression between duplicate genes inferred from microarray data Z Gu, D Nicolae, HHS Lu, WH Li Trends in genetics 18 (12), 609-613	2002
Extent of gene duplication in the genomes of Drosophila, nematode, and yeast Z Gu, A Cavalcanti, FC Chen, P Bouman, WH Li Molecular biology and evolution 19 (3), 256-262	2002
Evolutionary analyses of the human genome WH Li, Z Gu, H Wang, A Nekrutenko Nature 409 (6822), 847-849	2001
Densities, length proportions, and other distributional features of repetitive sequences in the human genome estimated from 430 megabases of genomic sequence Z Gu, H Wang, A Nekrutenko, WH Li Gene 259 (1-2), 81-88	2000