Zhenglong Gu Laboratory: People

Gu Laboratory: people


Principal Investigator

 
Zhenglong Gu
Zhenglong Gu

Assistant Professor
Division of Nutritional Sciences
Cornell Center for Comparative and Population Genomics
Cornell University

 

Current Lab Members

 
Xiaoxian Guo
Xiaoxian Guo

Visiting Student

Zhejiang University

I am interested in dissecting the genetic basis of quantitative traits using yeast as an model.

 
Josephine Wee
Josephine Wee

Postdoctoral Associate

Research Description: Coming Soon

 
Tianyi Zhang
Tianyi Zhang

Postdoctoral Associate

My research mainly focuses on the TP53 and MTHFR genes in humans, which are sensitive to stress signals, especially temperature. Their various single-nucleotide polymorphisms may lead to different responses in different environments. Utilizing DNA editing technologies, our goal is to develop in vitro models with TP53 and MTHFR mutations respectively, and explore the relationship between these mutations and temperature adaptation. Our work also includes developing effective DNA editing methods for mammalian mitochondrial DNA.

 
Lingfeng Tang
Lingfeng Tang

Postdoctoral Associate

Research Description: Coming Soon

 
Inna Sirota
Inna Sirota

Graduate Student

I am interested in the role of mitochondrial DNA (mtDNA) in cancer. Specifically, I am interested in the effects of mtDNA heteroplasmy on the cancer phenotype and drug response. Another approach that I am taking to define the role of mtDNA in cancer is through the cybrid model. The cybrid model is the fusion of an enucleated cell with a cell without mtDNA, so that there is a nucleus from one cell and mtDNA from another. Through both of these approaches, we hope to better understand the influence of mitochondrial function on the cancer phenotype.

 
Ruoyu Zhang
Ruoyu Zhang

Graduate Student

I am interested in investigating mtDNA variants by analyzing next generation sequencing data, I am currently focusing on two projects:

1. Estimate mtDNA heteroplasmies and mtDNA copy number from next generation sequencing data, and investigate how they are associated with health trait in general population.

2. Explore the dynamics of mtDNA heteroplasmy, how the heteroplasmy frequencies change over time and whether the changes can affect gene expression profiles.

 

Past Lab Members

 
Kaixiong Ye
Kaixiong Ye

Graduate Student

With the rapid development of next-generation sequencing and the plummetting of sequencing price, personal genome information is no longer out of reach. I am interested in exploring the possibility of integrating personal genome information into nutritional intervention to tailor personalized diet.
Also, I am working on QTL mapping in yeast to identify loci underlying complex traits, such as drug resistance. Especially, we are exploring the genetic interactions (epistasis) beneath complex traits and trying to improve QTL mapping by taking into account genetic interactions.

 
Zhe Wang
Zhe Wang

Postdoc

My research mainly focuses on the post-transcriptional regulation network, which includes processing, export, localization, turnover and translation of mRNAs, adding substantial complexity to the control of gene expression. I am especially interested in the 3'UTR binding proteins in diverse yeast models, which play important roles in the evolution of an efficient fermentative capability. This unique metabolic trait can be exploited in the biofuel production. Utilizing the next-generation sequence technologies, our research strives to provide a better view of complex biological system across the evolutionary time scale.

 
Brandon Barker
Brandon Barker

Graduate Student

I am interested in the relationship between the cell-cycle and energy metabolism in S. cerevisiae. By using mathematical modeling and dynamical information, we hope to better understand the cell-cycle's relationship to energy metabolism. Two components of the employed methods we are further developing are reconstruction of regulatory networks and constraint-based modeling.

 
Hong Chen
Hong Chen

Graduate Student (2007~2012)

I am using the yeast as model to study the molecular mechanism how the aerobic fermentation is evolved. we are interested to see if Whole genome duplication during yeast evolution is contributed to aerobic fermentation, and then focus on individual gene duplications for further study, such as TOR gene. we are also intereted to know if FBP regulation of PYK1 is important for aerobic fermentation. These studies might shed insight on an alternative approach of cancer therapy, since cancer cells also use aerobic fermentation to meet their energy needs.

Lin Xu
Lin Xu

Graduate Student (2006~2012)

I am interested in exploring functional genomics by using high-throughput yeast genetic interaction data. My projects focus on elucidate how genetic interactions are distributed underlying complex traits. We found that major effect genes underlying complextraits are well connected with each other through genetic interaction, a previously unknown genetic architecture of complex traits that can lead to difficulties in genetic mapping. Our results call on new methods using genetic interaction information in genetic mapping of organism phenotypic difference,including human diseases.

Huifeng Jiang
Huifeng Jiang

Postdoc (2008~2012)

My major research is to investigate the evolutionary mechanisms of transcriptional and translational regulation for a novel pathway which evolved after whole genome duplication in yeast: aerobic fermentation, which displays similar metabolic properties as cancer cells. Systematically studying the regulatory mechanisms of aerobic fermentation in yeast would shed light on cancerogenesis.

Jonathan Burris
Jonathan Burris

Undergraduate Research Student

Faraz Butte
Faraz Butte

Undergraduate Research Student

 
Roberto Flores

Lab Manager (2009-2010)

Current Status:
Ph.D. of Biology
The Department of Biology, Boston College

Research Interest:
The Warburg Theory of Cancer and The Metabolism of Cancer

 
 
Haijing Yu

Visiting Scholar (2009-2010)

Yunnan University, Kunming, China

 
 
Wenjun Guan

Visiting Scholar (2006-2008)

Zhejiang University, Hangzhou, China

 
 
Michael Zettel

Lab Manager (2006)

 
 
Gregory Calosso

Undergraduate Research Student(2007-2008)

 
 
David Pinney

Undergraduate Research Student(2006-2008)